Enzymatic Activities of (Catalase) (Highmolecula Electrolyte) Complexes. II

Cu(II)-disulfide complexes display simultaneous superoxide dismutase- and catalase-like activities.

Superoxide is a potentially toxic by-product of cellular metabolism. We have addressed here the in vitro ability of complexes formed between copper(II) ions and various biologically-occurring disulfides (RSSR: oxidized glutathione, cystine, homocystine and α-lipoic acid) to react with superoxide. The studied complexes were found to react with superoxide (generated by a xanthine/xanthine oxidase...

Antineoplastic and Cytotoxic Activities of Nickel(II) Complexes of Thiosemicarbazones

Nickel(II) complexes of thiosemicarbazons were observed to be potent cytotoxic agents in human and rodent tissue cultured tumor cells. Each compound demonstrated a slightly different profile in the various histological types of tumors. The nickel complex of Appip demonstrated the most potent in vivo activity in the Ehrlich ascites carcinoma. This agent selectively inhibited L1210 DNA and purine...

The antimicrobial and antibiofilm activities of copper(II) complexes.

Biofilm-related bacterial infections pose a significant problem, as they are generally more tolerant to antibiotics and the immune system. Development of novel compounds with antibiofilm activity is therefore paramount. In this study we have analysed metal complexes of the general structure [M(IL)(AL)](2+) (where IL represents functionalised 1,10-phenanthrolines and AL represents 1S,2S- or 1R,2...

The composition of catalase-peroxide complexes.

Mn(II), Ni(II), and Cu(II) Complexes of Artmisinin Derivatives: Synthesis, Characterization and Antimicrobial Activities

A range of transition metals ligated by sesquiterpene lactone-artesunate (ATS) have been investigated. Syntheses of Cu(II), Ni(II), and Mn(II) complexes of decahydro-3,6,9-trimethyl3,12-epoxy-12H-pyrano[4,3-j]1,2-benzodioxepin10-ol hydrogen succinate were prepared by a direct aqueous substitution reaction in methanol. Structural elucidations of the complexes were determined using X-Ray Diffract...